EFFICACY OF MULTIPLE-DOSE HALOFANTRINE IN TREATMENT OF CHLOROQUINE-RESISTANT FALCIPARUM MALARIA IN CHILDREN IN KENYA
Identifieur interne : 003209 ( Main/Exploration ); précédent : 003208; suivant : 003210EFFICACY OF MULTIPLE-DOSE HALOFANTRINE IN TREATMENT OF CHLOROQUINE-RESISTANT FALCIPARUM MALARIA IN CHILDREN IN KENYA
Auteurs : W. M Watkins [Kenya] ; J. D Lury [Kenya] ; D. Kariuki [Kenya] ; D. K Koech [Kenya] ; J. A Oloo [Kenya] ; M. Mosoba [Royaume-Uni] ; M. Mjomba [Royaume-Uni] ; H. M Gilles [Royaume-Uni]Source :
- The Lancet [ 0140-6736 ] ; 1988.
English descriptors
- Teeft :
- Alkaline phosphatase, Alternative drugs, Aspirin, Bilirubin, Body weight, Cell count, Chloroquine, Clinical chemistry, Clinical trials, Dos, Falciparum, Falciparum infections, Falciparum malana, Falciparum malaria, First study, First week, Halofantrine, Halofantrine hydrochloride, Halofantrine therapy, Healthy humans, Infarction, Kenya, Kenya coast, Kenya ministry, Kilifi, Kilifi district hospital, Kilifi study, Lake malawi, Liverpool school, Malaria, Malawi, Malindi, Malindi study, Myocardial infarction, Normal conditions, Normal limits, Normal range, Parasitaemia, Parasite, Parasite clearance time, Parasite counts, Parasite sensitivity, Phenanthrene methanol compound halofantrine, Physical examination, Plasmodium, Plasmodium falciparum, Proc natl acad, Prostacyclin, Prostaglandin, Prostaglandin endoperoxides, Rieckmann, Rieckmann microtest, Rieckmann microtests, Schizont maturation, Second trial, Secondary prevention, Serum aspartate, Single dose, Test concentrations, Tropical medicine, Unstable angina, Vesterqvist, Vivo production, Wellcome trust, West africa, West shore.
Abstract
Abstract: Halofantrine hydrochloride given to 46 Kenyan children with falciparum malaria at 10 mg/kg for two doses, and to 60 other children at 8 mg/kg for three doses, resulted in rapid parasite clearance, mean parasite clearance times being 45·4 h and 54·8 h, respectively. In-vitro chemosensitivity tests showed that most infections were due to chloroquine-resistant parasites, and that parasite maturation was inhibited by considerably lower concentrations of halofantrine than of chloroquine.
Url:
DOI: 10.1016/S0140-6736(88)92538-X
Affiliations:
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Le document en format XML
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M" last="Watkins">W. M Watkins</name><affiliation wicri:level="1"><country xml:lang="fr">Kenya</country><wicri:regionArea>Biomedical Sciences Research Centre, Kenya Medical Research Institute (KEMRI), Nairobi;</wicri:regionArea><wicri:noRegion>Nairobi;</wicri:noRegion></affiliation></author><author><name sortKey="Lury, J D" sort="Lury, J D" uniqKey="Lury J" first="J. D" last="Lury">J. D Lury</name><affiliation wicri:level="1"><country xml:lang="fr">Kenya</country><wicri:regionArea>Wellcome Trust Research Laboratories, Nairobi;</wicri:regionArea><wicri:noRegion>Nairobi;</wicri:noRegion></affiliation></author><author><name sortKey="Kariuki, D" sort="Kariuki, D" uniqKey="Kariuki D" first="D" last="Kariuki">D. 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A Oloo</name><affiliation wicri:level="1"><country xml:lang="fr">Kenya</country><wicri:regionArea>Clinical Research Centre, KEMRI, Nairobi;</wicri:regionArea><wicri:noRegion>Nairobi;</wicri:noRegion></affiliation></author><author><name sortKey="Mosoba, M" sort="Mosoba, M" uniqKey="Mosoba M" first="M" last="Mosoba">M. Mosoba</name><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Vector Borne Diseases, Kenya Ministry of Health;</wicri:regionArea><wicri:noRegion>Kenya Ministry of Health;</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Parasitology, Liverpool School of Tropical Medicine, Liverpool;</wicri:regionArea><wicri:noRegion>Liverpool;</wicri:noRegion></affiliation></author><author><name sortKey="Mjomba, M" sort="Mjomba, M" uniqKey="Mjomba M" first="M" last="Mjomba">M. Mjomba</name><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Kilifi District Hospital;</wicri:regionArea></affiliation></author><author><name sortKey="Gilles, H M" sort="Gilles, H M" uniqKey="Gilles H" first="H. M" last="Gilles">H. M Gilles</name><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Pharmacology and Therapeutics, University of Liverpool, Liverpool</wicri:regionArea><wicri:noRegion>Liverpool</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">The Lancet</title><title level="j" type="abbrev">LANCET</title><idno type="ISSN">0140-6736</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1988">1988</date><biblScope unit="volume">332</biblScope><biblScope unit="issue">8605</biblScope><biblScope unit="page" from="247">247</biblScope><biblScope unit="page" to="250">250</biblScope></imprint><idno type="ISSN">0140-6736</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0140-6736</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Alkaline phosphatase</term><term>Alternative drugs</term><term>Aspirin</term><term>Bilirubin</term><term>Body weight</term><term>Cell count</term><term>Chloroquine</term><term>Clinical chemistry</term><term>Clinical trials</term><term>Dos</term><term>Falciparum</term><term>Falciparum infections</term><term>Falciparum malana</term><term>Falciparum malaria</term><term>First study</term><term>First week</term><term>Halofantrine</term><term>Halofantrine hydrochloride</term><term>Halofantrine therapy</term><term>Healthy humans</term><term>Infarction</term><term>Kenya</term><term>Kenya coast</term><term>Kenya ministry</term><term>Kilifi</term><term>Kilifi district hospital</term><term>Kilifi study</term><term>Lake malawi</term><term>Liverpool school</term><term>Malaria</term><term>Malawi</term><term>Malindi</term><term>Malindi study</term><term>Myocardial infarction</term><term>Normal conditions</term><term>Normal limits</term><term>Normal range</term><term>Parasitaemia</term><term>Parasite</term><term>Parasite clearance time</term><term>Parasite counts</term><term>Parasite sensitivity</term><term>Phenanthrene methanol compound halofantrine</term><term>Physical examination</term><term>Plasmodium</term><term>Plasmodium falciparum</term><term>Proc natl acad</term><term>Prostacyclin</term><term>Prostaglandin</term><term>Prostaglandin endoperoxides</term><term>Rieckmann</term><term>Rieckmann microtest</term><term>Rieckmann microtests</term><term>Schizont maturation</term><term>Second trial</term><term>Secondary prevention</term><term>Serum aspartate</term><term>Single dose</term><term>Test concentrations</term><term>Tropical medicine</term><term>Unstable angina</term><term>Vesterqvist</term><term>Vivo production</term><term>Wellcome trust</term><term>West africa</term><term>West shore</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Halofantrine hydrochloride given to 46 Kenyan children with falciparum malaria at 10 mg/kg for two doses, and to 60 other children at 8 mg/kg for three doses, resulted in rapid parasite clearance, mean parasite clearance times being 45·4 h and 54·8 h, respectively. In-vitro chemosensitivity tests showed that most infections were due to chloroquine-resistant parasites, and that parasite maturation was inhibited by considerably lower concentrations of halofantrine than of chloroquine.</div></front></TEI><affiliations><list><country><li>Kenya</li><li>Royaume-Uni</li></country></list><tree><country name="Kenya"><noRegion><name sortKey="Watkins, W M" sort="Watkins, W M" uniqKey="Watkins W" first="W. M" last="Watkins">W. M Watkins</name></noRegion><name sortKey="Kariuki, D" sort="Kariuki, D" uniqKey="Kariuki D" first="D" last="Kariuki">D. Kariuki</name><name sortKey="Koech, D K" sort="Koech, D K" uniqKey="Koech D" first="D. K" last="Koech">D. K Koech</name><name sortKey="Lury, J D" sort="Lury, J D" uniqKey="Lury J" first="J. D" last="Lury">J. D Lury</name><name sortKey="Oloo, J A" sort="Oloo, J A" uniqKey="Oloo J" first="J. A" last="Oloo">J. A Oloo</name></country><country name="Royaume-Uni"><noRegion><name sortKey="Mosoba, M" sort="Mosoba, M" uniqKey="Mosoba M" first="M" last="Mosoba">M. Mosoba</name></noRegion><name sortKey="Gilles, H M" sort="Gilles, H M" uniqKey="Gilles H" first="H. M" last="Gilles">H. M Gilles</name><name sortKey="Mjomba, M" sort="Mjomba, M" uniqKey="Mjomba M" first="M" last="Mjomba">M. Mjomba</name><name sortKey="Mosoba, M" sort="Mosoba, M" uniqKey="Mosoba M" first="M" last="Mosoba">M. Mosoba</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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